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New Hopes And Advancements In Prostate Cancer Treatment

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Prostate cancers are the most common type of male cancers

Last updated on September 10th, 2022 at 06:49 pm

Prostate cancers are the most common type of male cancers

Prostate cancers affect approximately 210,000 new men each year in the United States alone.

Local treatments usually cure patients with localized diseases, but up to one-third of them may show recurrence after 10 yrs.

At present, there is no ideal way to manage these men. Radiotherapy given for suspected recurrent malignancy after surgery may provide a long-term benefit in some cases, but the use of androgen suppression therapy (AST) is controversial.

While ADT effectively lowers serum prostate-specific antigen (PSA) levels in most men with advanced disease, there is no evidence that it improves overall patient outcomes. However, the treatment carries an increased risk for side effects, including sexual dysfunction, urinary incontinence, and bowel symptoms. These adverse events may be associated with decreased quality of life.

Department of Oncology, Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel

Prostate cancer diagnosis

Men who relapse after castration therapy have a varied natural course. Some may be asymptomatic for many months or even several decades.

Prostate cancer treatment

PectaSol® Modified Citrus Pectin (P-MCP; ecoNugenics Inc, Santa Rosa, CA, USA) is derived from the pith of citrus fruit peels and treated with enzymes, pH, and temperature. It is an orally administered competitive inhibitor of galectin-3 (Gal-3), a carbohydrate-binding protein involved in cancer pathogenesis.

P-MCP is a dietary supplement form of pectin comprised of low-molecular-weight and low degree of esterification to allow absorption from the small intestinal epithelium into the circulation.

prostate cancer

Prostate cancer symptoms – Inclusion Criteria

Eligible patients were ≥21 years old and had histologically proven prostatic adenocarcinoma. All participants had undergone radical prostatectomy and/or external beam radiation therapy

Toxicity and Disease Status at Follow-Up Monthly Assessments

Patients were evaluated for toxicities, physical exams, serum PSA, testosterone, CRP, and galectin-3 levels.

Statistical Analysis

The analysis was performed using the first six months of administration with the investigational supplement.
  • This study’s primary efficacy endpoint was the rate of patients without PSA progression (defined as an increase of ≥25% from baseline) and/or patients with improvement (lengthening) of PSADT versus baseline.
  • PSADT calculation used the natural log of two divided by the slope found from measuring a linear regression with the natural log of PSA against time (months). All the available PSA measurements in the year before patient enrollment were used to calculate baseline pre-treatment PSADT.
  • The post-baseline PSADT was calculated using PSA levels obtained at baseline and monthly during treatment.
  • Secondary endpoints were the rate of patients without radiologic progression, toxicity, and treatment benefits according to the PSADT risk grouping (e.g., poor < 3 months, intermediate 3–8.99 months, and good ≥ nine months).

In 2004 Webmd published ” A new study shows men who drink four or more glasses of red wine per week have a nearly 50% lower risk of prostate cancer than non-drinkers. In addition, researchers found that red wine’s protective effects appear to be even stronger against the most dangerous and aggressive forms of prostate cancer.”

2019 a research published at https://www.avogel.co.uk/health/enlarged-prostate/how-does-alcohol-affect-an-enlarged-prostate/” As men age, the size of their Prostate tends to increase.

This is called Benign Prostatic Hyperplasia (BPH). BPH can cause symptoms such as frequent urination and slow urine flow. This is known as an enlarged prostate, or benign prostatic hyperplasia (BPH), and can contribute to symptoms such as frequent urination and poor urine flow. 

Researchers say drinking alcohol may help prevent some types of cancers.  Alcohol is inflammatory in its effects, which means that it worsens the inflammation that is already present in the prostate cells, thus blocking the flow of urine further.

There aren’t any known causes of enlargement of the prostate. However, certain conditions can make your Prostate grow larger. Age plays a huge role in the development of Enlarged Prostatitis. Men who are over the age of 50 are more likely to develop an enlarged Prostatic. Some studies show that hormone levels fluctuate as we get older. These fluctuations may cause the prostate to enlarge. Lifestyles such as lack of exercise or cigarette smoke can also lead to the growth of an enlarged Prostatic. 

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